供者血液警戒在预备性血浆分离术期间。
Donor Hemovigilance during Preparatory Plasmapheresis.
机构信息
Haema AG, Leipzig, Germany.
E.B.P.S.-Logistics GmbH, Vienna, Austria.
出版信息
Transfus Med Hemother. 2014 Apr;41(2):123-33. doi: 10.1159/000357991. Epub 2014 Feb 17.
BACKGROUND
Reports on unexpected donor events (UEs) during preparatory plasmapheresis (PPP) are scarce, and rarely consider technical UEs.
METHODS
Defined local and systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into the PMS. Medical directors reviewed entries quarterly. EBPS compiled data on donors, donations and UEs from January 1, 2008 to June 30, 2011.
RESULTS
66,822 UEs were observed during 1,107,846 PPPs for a corrected incidence of 6.55% (1.4% local, 0.55% systemic, 4.6% technical UEs). 3.36% of PPPs were accompanied by 1 UE and 1.18% by >1 UE (2-5). 13.7% of donors undergoing PPP for the first time, 9.7% of those having a second PPP and 4.0% of those having a third or more PPPs were associated with UEs. Most common UEs were repeated venipuncture, and broken-off collection due to venous access problems and small hematomas. Severe systemic UEs occurred at a rate of 36 per 100,000 PPPs.
CONCLUSIONS
Technical UEs were common with PPP. UEs accompanied first and second donations significantly more frequently than for subsequent donations.
背景
关于预备性血浆分离术（PPP）期间意外供者事件（UE）的报告很少，且很少考虑技术 UE。
方法
根据严重程度对局部和全身 UE 进行分级；技术 UE 不分级。2008 年 1 月 1 日，E.B.P.S.-Logistics（EBPS）为血浆管理软件（PMS）安装了 UE 模块。供者室医生每天将 UE 输入到 PMS 中。医疗主任每季度审查一次条目。EBPS 从 2008 年 1 月 1 日至 2011 年 6 月 30 日，收集了供者、供者和 UE 的数据。
结果
在 1107846 次 PPP 中观察到 66822 次 UE，校正发生率为 6.55%（1.4%为局部 UE，0.55%为全身 UE，4.6%为技术 UE）。3.36%的 PPP 伴有 1 次 UE，1.18%的伴有 >1 次 UE（2-5）。首次接受 PPP 的供者中，13.7%、第二次接受 PPP 的供者中 9.7%和第三次或更多次接受 PPP 的供者中 4.0%与 UE 相关。最常见的 UE 是重复静脉穿刺和因静脉通路问题和小血肿而导致的采集管脱落。严重的全身 UE 发生率为每 100000 次 PPP 36 例。
结论
技术 UE 在 PPP 中很常见。UE 伴随首次和第二次供者捐献比伴随后续捐献更频繁。
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