Wingard J R, Dick J D, Merz W G, Sandford G R, Saral R, Burns W H
Infect Immun. 1982 Aug;37(2):833-6. doi: 10.1128/iai.37.2.833-836.1982.
Prior reports from this institution indicated that Candida tropicalis was more pathogenic than C. albicans in oncology patients. Pairs of clinical isolates of C. tropicalis and C. albicans recovered from similar patients at other institutions were examined to determine their relative virulence. After intravenous inoculation in normal mice, three pairs of isolates had no significant differences in the 50% lethal dose, and one C. tropicalis isolate was less virulent than its companion C. albicans isolate. In contrast, in mice treated with antibiotics and cytarabine, an antineoplastic drug which damages the gastrointestinal mucosa and produces granulocytopenia, oral inoculation of yeast cells produced striking differences in the 50% infective dose: each C. tropicalis isolate was more virulent than the companion C. albicans isolate from the same institution. The increased virulence of the C. tropicalis isolates compared with the C. albicans isolates when given orally to compromised mice parallels clinical observations in compromised patients.
该机构之前的报告表明，热带假丝酵母菌在肿瘤患者中比白色念珠菌更具致病性。对从其他机构类似患者中分离出的热带假丝酵母菌和白色念珠菌临床菌株对进行检测，以确定它们的相对毒力。在正常小鼠中静脉接种后，三对菌株的半数致死剂量无显著差异，一株热带假丝酵母菌菌株的毒力低于其对应的白色念珠菌菌株。相比之下，在用抗生素和阿糖胞苷（一种会损害胃肠道黏膜并导致粒细胞减少的抗肿瘤药物）处理的小鼠中，口服接种酵母细胞后，半数感染剂量出现了显著差异：来自同一机构的每株热带假丝酵母菌菌株都比对应的白色念珠菌菌株毒力更强。与白色念珠菌菌株相比，给免疫功能受损的小鼠口服热带假丝酵母菌菌株时其毒力增加，这与免疫功能受损患者的临床观察结果相似。
