老龄大鼠胰岛的功能同质性

Functional homogeneity of pancreatic islets of aging rats.

作者信息

Reaven E, Solomon R, Azhar S, Reaven G

出版信息

Metabolism. 1982 Sep;31(9):859-60. doi: 10.1016/0026-0495(82)90172-x.

Abstract

Islest from different regions of pancreases of aging rats were compared for size and variations of response to glucose stimulation. The results show that pancreatic islets from the ventral-duodenal and splenic regions of 12-mo-old retired breeder. Spraque dawley rats are comparable in all respects measured: thus, pancreatic regional differences cannot explain the age-associated reduction in beta cell secretory response noted in previous studies.

摘要

对来自老年大鼠胰腺不同区域的胰岛进行了大小比较以及对葡萄糖刺激反应的差异比较。结果显示，12月龄退休种鼠斯普拉格-道利大鼠的腹侧十二指肠和脾脏区域的胰岛在所有测量方面均具有可比性；因此，胰腺区域差异无法解释先前研究中所指出的与年龄相关的β细胞分泌反应降低。