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[中风后中枢性疼痛的丘脑中央中核毁损术——其疗效与局限性]

[Centro-median thalamotomy for central pain following stroke --its effectiveness and limits].

作者信息

Niizuma H, Kwak R, Ohyama H, Ikeda S, Suzuki J, Saso S

出版信息

No Shinkei Geka. 1982 Jun;10(6):629-35.

PMID:6750432
Abstract

Centro-median thalamotomy was performed on 18 patients with central pain caused by cerebrovascular disease. Fourteen were males and four were females. Clinical diagnoses were thalamic pain in 17 cases including cheiro-orale syndrome in one case and phantom limb pain in one case. CT scans were performed on six recent cases. Four cases had a small low density sera in the thalamus. The other two cases had no remarkable findings. The target was 7.5-11.0 nm posterior to the middle point of the intercommissural line, 1.0 mm below-2.0 mm above that line and 5.5-10.0 mm from the midline. Unilateral lesion was made on 15 cases. Postoperatively, five cases had almost completely relief of pain and four cases had partial improvement. The duration of pain relief was, however, less than two months in four cases, and between three and seven months in four cases. One case had a pain free period for seven months. But, then, severe dysesthesia appeared. Six cases had no pain relief by unilateral lesion. Two cases had no pain relief by bilateral lesions. In the remaining case, unilateral lesion was effective for six months. Then lesion of opposite side was made, but the result was unsatisfactory. The durations from the onset of apoplectic attack to the occurrence of pain were between four months and three years in ten effective cases, and within three months in six among eight failed cases. Many surgical and medical treatments have been attempted for central pain. However, ideal method is still not appeared. Centro-median thalamotomy was effective for 56% of the patients with central pain. But in most of the cases, the duration of pain relief is about a half year at the longest. And may be, this is the limit of effectiveness of centro-median thalamotomy for central pain.

摘要

对18例由脑血管疾病引起中枢性疼痛的患者实施了丘脑中央中核切开术。其中男性14例,女性4例。临床诊断为丘脑痛17例,包括1例口手综合征和1例幻肢痛。对6例近期病例进行了CT扫描。4例丘脑有小的低密度区。另外2例无明显异常。靶点位于连合间线中点后方7.5 - 11.0毫米,该线下方1.0毫米至上方2.0毫米,距中线5.5 - 10.0毫米。15例进行了单侧毁损。术后,5例疼痛几乎完全缓解,4例部分改善。然而,4例疼痛缓解持续时间不足2个月,4例在3至7个月之间。1例无痛期为7个月。但随后出现了严重的感觉异常。6例单侧毁损后疼痛未缓解。2例双侧毁损后疼痛未缓解。在其余1例中,单侧毁损在6个月内有效。然后对侧进行毁损,但效果不满意。10例有效病例中,从中风发作到疼痛出现的时间在4个月至3年之间,8例无效病例中有6例在3个月内。对于中枢性疼痛,已经尝试了许多手术和药物治疗。然而,理想的方法仍未出现。丘脑中央中核切开术对56%的中枢性疼痛患者有效。但在大多数情况下,疼痛缓解的最长持续时间约为半年。而且,这可能是丘脑中央中核切开术治疗中枢性疼痛有效性的极限。

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