Faergeman O, Meinertz H, Hylander E, Fischerman K, Jarnum S, Nielsen O V
Gut. 1982 Jul;23(7):558-63. doi: 10.1136/gut.23.7.558.
Ten patients with familial hypercholesterolaemia were subjected to partial ileal by-pass surgery. Plasma cholesterol fell by 41 and 38% and low-density lipoprotein cholesterol by 51 and 46% after six and 18 months respectively. High-density and very low-density lipoprotein cholesterol and plasma triglycerides were unaffected. Alanine aminotransferase increased transiently in half of the patients. Diarrhoea and slight steatorrhoea troubled most of the patients for the duration of 18 months' period of observation. Other long-term side effects were slight but significant increase in the renal excretion of oxalic acid and reduction in the intestinal absorption of calcium. The study shows that this operation has metabolic side-effects that warrant continued medical care of these patients.
十名家族性高胆固醇血症患者接受了部分回肠旁路手术。分别在术后六个月和十八个月时，血浆胆固醇下降了41%和38%，低密度脂蛋白胆固醇下降了51%和46%。高密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和血浆甘油三酯未受影响。半数患者的丙氨酸转氨酶短暂升高。在18个月的观察期内，腹泻和轻度脂肪泻困扰着大多数患者。其他长期副作用包括草酸肾排泄略有但显著增加以及肠道钙吸收减少。该研究表明，这种手术具有代谢副作用，需要对这些患者持续进行医疗护理。
