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使用可移动电极绘制行为基质的心理物理学方法。

Psychophysical method for mapping behavioral substrates using a moveable electrode.

作者信息

Miliaressis E, Rompré P P, Durivage A

出版信息

Brain Res Bull. 1982 Jun;8(6):693-701. doi: 10.1016/0361-9230(82)90097-1.

DOI:10.1016/0361-9230(82)90097-1
PMID:6754010
Abstract

With the use of moveable electrodes, 28 rat mesencephalic sites were examined for self-stimulation behavior (SS). The relative importance of each site in SS was established according to (1) a traditional method which consists of comparing sites based on the rates of responding (2) a psychophysical procedure based on the pulse frequency required at each site in order for the stimulation to elicit a criterion behavioral performance. It was shown that anatomical conclusions reached by the use of behavioral output procedures depend purely on the arbitrary choice of stimulation parameters. It was also demonstrated that the combination of moveable electrodes with psychophysical measurements results in enhanced mapping resolution and enables one to trace the boundaries of behaviorally relevant structures and pathways with significantly better confidence.

摘要

使用可移动电极对28个大鼠中脑位点进行了自我刺激行为(SS)检测。根据以下方法确定每个位点在SS中的相对重要性:(1)一种传统方法,即基于反应率比较不同位点;(2)一种心理物理学程序,该程序基于每个位点为引发标准行为表现所需的脉冲频率。结果表明,通过行为输出程序得出的解剖学结论完全取决于对刺激参数的任意选择。研究还表明,将可移动电极与心理物理学测量相结合可提高图谱分辨率,并能更有信心地追踪与行为相关的结构和通路的边界。

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