前列环素和前列腺素E2对犬胰液分泌的影响。

Effects of prostacyclin and prostaglandin E2 on the secretion of pancreatic juice in the dog.

Iwatsuki K, Chiba S

Clin Exp Pharmacol Physiol. 1982 Sep-Oct;9(5):495-8. doi: 10.1111/j.1440-1681.1982.tb00823.x.

Abstract

Effects of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on the secretion of pancreatic juice were investigated in preparations of the blood-perfused canine pancreas. 2. PGI2 did not affect the basal or secretin-induced pancreatic secretion. However, PGE2 caused a dose-related inhibition of the secretin-induced secretion not only in preparations of the constant pressure perfusion but also of the constant flow perfusion. 3. These results suggest that PGE2, but not PGI2, may control the secretory mechanism of the pancreatic secretion in dogs.

摘要

在血液灌注的犬胰腺制备物中研究了前列环素（PGI2）和前列腺素E2（PGE2）对胰液分泌的影响。2. PGI2不影响基础或促胰液素诱导的胰腺分泌。然而，PGE2不仅在恒压灌注制备物中，而且在恒流灌注制备物中均引起促胰液素诱导分泌的剂量相关抑制。3. 这些结果表明，PGE2而非PGI2可能控制犬胰腺分泌的分泌机制。