Ferreira S H, Nakamura M, de Abreu Castro M S
Prostaglandins. 1978 Jul;16(1):31-7. doi: 10.1016/0090-6980(78)90199-5.
Hyperalgesia induced in rat paws or dog knee joints by prostacyclin (PGI2) and prostaglandin E2 was measured by a modification of the Randall-Selitto method (1) or by the degree of incapacitation (2). In both species PGI2 induced an immediate hyperalgesic effect but the effect of PGE2 had a longer latency. Low doses of PGI2 caused a short lasting effect but PGE2, large doses of PGI2 or successive administration of small doses of PGI2 caused a long lasting effect. It is suggested that prostacyclin mediates rat paw hyperalgesia induced by carrageenin. The long lasting hyperalgesic effect of PGE2 and high doses of PGI2 is possibly an indirect effect caused by stimulation of a sensory nerve sensitising mechanism.
通过对Randall-Selitto方法（1）进行改进或根据失能程度（2）来测量前列环素（PGI2）和前列腺素E2在大鼠爪部或犬膝关节诱发的痛觉过敏。在这两个物种中，PGI2均诱发即时痛觉过敏效应，但PGE2的效应潜伏期更长。低剂量的PGI2产生短暂效应，而PGE2、高剂量的PGI2或连续给予小剂量的PGI2则产生持久效应。提示前列环素介导角叉菜胶诱导的大鼠爪部痛觉过敏。PGE2和高剂量PGI2的持久痛觉过敏效应可能是由刺激感觉神经致敏机制引起的间接效应。
