Iwatsuki K, Horiuchi A, Yonekura H, Kuroda T, Chiba S
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:263-71.
Correlation between pancreatic exocrine secretion and prostaglandin (PG) output was investigated in the isolated and blood-perfused pancreas in pentobarbital-anesthetized dogs. Intraarterial injections of low doses of secretin (0.03-1 units) caused dose-dependent increases in the secretion of pancreatic juice without affecting the output of PGs. Increased secretion was not modified by indomethacin treatment (5 mg/kg, i.v.). Intra-arterial injections of high doses of secretin (4 and 8 units) stimulated the output of both pancreatic secretin and PGE2 and 6-keto-PGF1 alpha into the blood of the pancreaticoduodenal vein dose-dependently. Increased output of PGs was completely inhibited by the indomethacin treatment, but pancreatic secretion was not inhibited. Total amylase and pancreatic isoamylase activities in the blood from the pancreaticoduodenal vein were increased by the injection of secretin (8 units, i.a.). These results suggest that there is no simple correlation between the ability of secretin to increase the pancreatic secretion and its ability to stimulate PGs synthesis in dog pancreas. Increased output of PGs may be due to the consequence of the acute pancreatitis induced by high doses of secretin.
在戊巴比妥麻醉的犬身上，对离体且有血液灌注的胰腺中胰外分泌与前列腺素（PG）分泌之间的相关性进行了研究。动脉内注射低剂量的促胰液素（0.03 - 1单位）会导致胰液分泌呈剂量依赖性增加，而不影响PG的分泌量。吲哚美辛处理（5毫克/千克，静脉注射）不会改变分泌增加的情况。动脉内注射高剂量的促胰液素（4和8单位）会剂量依赖性地刺激胰液素以及PGE2和6 - 酮 - PGF1α分泌进入胰十二指肠静脉血液中。PG分泌量的增加被吲哚美辛处理完全抑制，但胰液分泌未受抑制。注射促胰液素（8单位，动脉内注射）会使胰十二指肠静脉血液中的总淀粉酶和胰腺同工淀粉酶活性增加。这些结果表明，在犬胰腺中，促胰液素增加胰液分泌的能力与其刺激PG合成的能力之间不存在简单的相关性。PG分泌量的增加可能是高剂量促胰液素诱导的急性胰腺炎的结果。
