Blitzer A
Laryngoscope. 1982 Nov;92(11):1219-38. doi: 10.1288/00005537-198211000-00001.
Regional behavioral differences have been observed clinically in epidermoid carcinoma of the head and neck. An animal model was developed for study, using homograft, transplanted epidermoid carcinoma in Fisher rats. Histopathologic review of tumors of the palate, base of tongue and larynx shows cartilage, arterial wall, surface epithelium and dense connective tissue containing elastic fibers to be relatively resistant to tumor invasion. Muscle, bone, vein and loose connective tissues were easily invaded. This correlates well with the known biochemical and immunological events in tumor invasion and host-tumor interactions. Regional metastasis occurred in two animals with base of tongue tumors. No distant metastases were found.
临床上已观察到头颈部表皮样癌存在区域行为差异。利用Fisher大鼠的同种移植表皮样癌建立了一种用于研究的动物模型。对腭、舌根和喉部肿瘤的组织病理学检查显示，软骨、动脉壁、表面上皮和含有弹性纤维的致密结缔组织对肿瘤侵袭相对具有抗性。肌肉、骨骼、静脉和疏松结缔组织容易受到侵袭。这与肿瘤侵袭和宿主-肿瘤相互作用中已知的生化和免疫事件密切相关。两只舌根肿瘤动物发生了区域转移。未发现远处转移。
