Haimann M H, Abrams G W, Edelhauser H F, Hatchell D L
Am J Ophthalmol. 1982 Nov;94(5):594-605. doi: 10.1016/0002-9394(82)90003-4.
We conducted a series of experiments on normal and diabetic rabbits to evaluate the effect of intraocular irrigating solutions on the lens. Lenticular clarity was studied in vivo in eyes undergoing vitreous cavity perfusions with various irrigating solutions. The clarity of isolated lenses incubated in these same solutions was also evaluated. In order to quantitate the cataractous changes observed, we measured the uptake of inulin (tagged with radioactive carbon) by isolated lenses. We found that balanced salt solution (BSS) and BSS Plus maintain excellent lens clarity in normal rabbits; that diabetic lenses are more likely to develop opacification than normal lenses, becoming cataractous when exposed to BSS Plus; and that adding supplemental glucose to BSS Plus allows this solution to maintain excellent lens clarity in diabetic rabbits.
我们对正常和糖尿病兔子进行了一系列实验，以评估眼内灌注液对晶状体的影响。在用各种灌注液进行玻璃体腔灌注的眼睛中，对晶状体的透明度进行了体内研究。还评估了在这些相同溶液中孵育的离体晶状体的透明度。为了量化观察到的白内障变化，我们测量了离体晶状体对菊粉（用放射性碳标记）的摄取。我们发现平衡盐溶液（BSS）和BSS Plus在正常兔子中能保持晶状体极佳的透明度；糖尿病晶状体比正常晶状体更容易出现浑浊，暴露于BSS Plus时会变成白内障；并且向BSS Plus中添加补充葡萄糖可使该溶液在糖尿病兔子中保持晶状体极佳的透明度。
