Koivisto V A, Groop L
Ann Clin Res. 1982;14 Suppl 34:74-9.
In normal man, physical training increase insulin binding to receptors and body sensitivity to insulin in vivo. In addition, serum lipid and lipoprotein profile changes which may decrease the risk for coronary heart disease. In juvenile onset diabetics, insulin requirements fall during physical training, the mechanism of this decline being yet unknown. There are no prospective studies regarding the prognostic effects of physical training in juvenile diabetes. However, if physical training can improve metabolic control and enhance body sensitivity to insulin resulting in lowered levels of plasma insulin, this may reduce the risk for both micro- and macrovascular complications. The possible adverse effects of exercise, hypoglycemia and excessive rise in counterregulatory hormones can be largely avoided by adequate insulin therapy.
在正常人群中，体育锻炼可增强胰岛素与受体的结合以及机体在体内对胰岛素的敏感性。此外，血清脂质和脂蛋白谱发生变化，这可能会降低冠心病风险。在青少年发病的糖尿病患者中，体育锻炼期间胰岛素需求量会下降，但其下降机制尚不清楚。目前尚无关于体育锻炼对青少年糖尿病预后影响的前瞻性研究。然而，如果体育锻炼能够改善代谢控制并增强机体对胰岛素的敏感性，从而降低血浆胰岛素水平，那么这可能会降低微血管和大血管并发症的风险。通过适当的胰岛素治疗，可在很大程度上避免运动、低血糖和反调节激素过度升高可能产生的不良影响。
