Johnson D D, Mitchell G E, Tucker R E, Hemken R W
J Anim Sci. 1982 Nov;55(5):1224-30. doi: 10.2527/jas1982.5551224x.
Eighteen preruminating calves obtained at approximately 38 d of age were used to determine whether the ruminant insulin response to propionate is an inherent response or one that is acquired because of ruminal propionate production. A liquid milk replacer diet was fed alone or with isocaloric additions of propionate [50 mmol . (kg BW . 75-1 . d-1] or glucose. Both additions caused a strong insulin response, but the response by propionate-fed calves appeared to be independent of plasma glucose concentrations during the early post-feeding hours. After receiving the experimental diets for 18 d, all calves were given an iv infusion or propionate [.035 mmol propionate . (kg BW . 75-1 . min-1 for 20 min]. All calves demonstrated a plasma insulin rise and glucose decline due to the infusions, but glucose-fed and propionate-fed calves appeared less sensitive to the iv propionate than the calves fed only milk replacer.
选用18头约38日龄的反刍前犊牛，以确定反刍动物对丙酸盐的胰岛素反应是一种内在反应，还是因瘤胃丙酸盐生成而获得的反应。单独饲喂液态代乳粉日粮，或添加等热量的丙酸盐[50 mmol·(kg体重·75-1·d-1)]或葡萄糖。两种添加物均引起强烈的胰岛素反应，但在采食后早期，饲喂丙酸盐的犊牛的反应似乎与血浆葡萄糖浓度无关。在接受实验日粮18天后，给所有犊牛静脉输注丙酸盐[0.035 mmol丙酸盐·(kg体重·75-1·min-1)，持续20分钟]。所有犊牛因输注均出现血浆胰岛素升高和葡萄糖下降，但与仅饲喂代乳粉的犊牛相比，饲喂葡萄糖和丙酸盐的犊牛对静脉输注丙酸盐的敏感性似乎较低。
