Krag C, De Rose G, Lyczakowski T, Freeman C R, Shapiro S H
Br J Plast Surg. 1982 Jul;35(3):328-36. doi: 10.1016/s0007-1226(82)90122-9.
In an experimental study in rabbits the effect of previous irradiation to the recipient vessels on the survival rate of free flaps was evaluated. Pre-operative radiotherapy was given in a single anterior neck field using a Cobalt60 unit, 1.25 MeV, SSD 80 cm in a fractionated dose corresponding to 5000 rad/5 weeks. An experimental model using paired data was established using two epigastric free flaps in each animal: one anastomosed to the irradiated vessels (carotid and jugular vein) and implanted outside the irradiated field and the other flap anastomosed to the normal femoral vessels and also implanted outside the irradiated field. In a sequential analysis it was found that free flaps anastomosed to irradiated recipient vessels within 12 weeks from the start of radiotherapy failed significantly more often than free flaps anastomosed to normal recipient vessels (p less than 0.10). This supports the view that preference should be given to the use of non-irradiated recipient vessels for microvascular transfer of free flaps.
在一项对兔子的实验研究中，评估了预先照射受体血管对游离皮瓣存活率的影响。术前放疗采用钴60装置在单个颈部前野进行，能量为1.25兆电子伏，源皮距80厘米，分割剂量相当于5000拉德/5周。使用配对数据建立了一个实验模型，每只动物采用两个上腹游离皮瓣：一个与受照射血管（颈动脉和颈静脉）吻合并植入照射野外，另一个皮瓣与正常股血管吻合并同样植入照射野外。在序贯分析中发现，放疗开始后12周内与受照射受体血管吻合的游离皮瓣失败的频率明显高于与正常受体血管吻合的游离皮瓣（p小于0.10）。这支持了在游离皮瓣微血管移植中应优先使用未受照射受体血管的观点。
