Chatenoud L, Baudrihaye M F, Kreis H, Goldstein G, Schindler J, Bach J F
Eur J Immunol. 1982 Nov;12(11):979-82. doi: 10.1002/eji.1830121116.
The anti-pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3-defined membrane antigen: after three injections, OKT3-treated patients showed a limited but significant number of OKT3- cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.
在四名人类肾移植受者中，每天给予抗全T细胞单克隆抗体OKT3，持续2周。该抗体导致外周T细胞迅速且显著减少，随后对OKT3定义的膜抗原进行体内抗原调节：三次注射后，接受OKT3治疗的患者显示出数量有限但具有统计学意义的T细胞性质的OKT3阴性细胞（由OKT4和OKT8定义），这些细胞在无单克隆抗体的情况下进行过夜体外培养后恢复了OKT3受体。
