Madsbad S, Hilsted J, Krarup T, Sestoft L, Christensen N J, Faber O K, Tronier B
Diabetologia. 1982 Dec;23(6):499-503. doi: 10.1007/BF00254298.
Hormonal, metabolic and cardiovascular responses to insulin induced hypoglycaemia were investigated in seven Type 1 (insulin-dependent) diabetic patients with residual B cell function, eight Type 1 diabetic patients without B cell function and six healthy subjects. No differences were found between the diabetic groups regarding nadir of glucose and rate of recovery to normoglycaemia. The patients with residual B cell function had a glucagon response to hypoglycaemia which was close to that of normal subjects. In patients without B cell function, the glucagon response to hypoglycaemia was present, albeit significantly smaller than in the patients with preserved B cell function (0.025 ng/ml, range 0.007-0.042 versus 0.054 ng/ml, range 0.029-0.087). The group without B cell function had signs of an exaggerated rate of lipolysis and ketogenesis compared with the patients with B cell function and the normal subjects.
对7名具有残余B细胞功能的1型（胰岛素依赖型）糖尿病患者、8名无B细胞功能的1型糖尿病患者和6名健康受试者，研究了胰岛素诱发低血糖时的激素、代谢及心血管反应。在糖尿病组之间，关于血糖最低点及恢复至正常血糖水平的速率未发现差异。具有残余B细胞功能的患者对低血糖的胰高血糖素反应与正常受试者相近。在无B细胞功能的患者中，存在对低血糖的胰高血糖素反应，尽管明显小于具有保留B细胞功能的患者（分别为0.025 ng/ml，范围0.007 - 0.042与0.054 ng/ml，范围0.029 - 0.087）。与具有B细胞功能的患者及正常受试者相比，无B细胞功能组有脂肪分解和生酮速率过高的迹象。
