Aymard J P, Herbeuval M, Herbeuval R, Witz F, Lederlin P, Legras B
Pathol Biol (Paris). 1982 Dec;30(10):855-7.
We studied the action of cimetidine at various concentrations on human hematopoeitic colony and cluster forming cells "in vitro" (CFUc). Bone marrow samples obtained from 31 patients with various hematological and neoplastic diseases were cultured in semisolid agar. When cimetidine was added to cultures there was a reduction of colony and macrocluster formation. At the concentration used in our study (20 micrograms/ml, 30 micrograms/ml, 40 micrograms/ml) these effects were not dose-related. We did not find any significant reduction of microcluster formation. These results are relevant with the hypothesis that histamine H2 receptors antagonists may have an inhibiting action on bone marrow CFUc proliferation. They point out the need for hematological surveillance during long-term cimetidine therapy.
我们研究了不同浓度的西咪替丁对人造血集落和集簇形成细胞“体外”（CFUc）的作用。从31例患有各种血液学和肿瘤性疾病的患者获取的骨髓样本在半固体琼脂中培养。当将西咪替丁添加到培养物中时，集落和大集簇的形成减少。在我们研究中使用的浓度（20微克/毫升、30微克/毫升、40微克/毫升）下，这些作用与剂量无关。我们未发现微集簇形成有任何显著减少。这些结果与组胺H2受体拮抗剂可能对骨髓CFUc增殖有抑制作用的假说相关。它们指出了在长期西咪替丁治疗期间进行血液学监测的必要性。
