Gil K M, Friedman M I
Physiol Behav. 1982 Nov;29(5):847-55. doi: 10.1016/0031-9384(82)90335-3.
Caloric intakes following injections of insulin were examined in male rats maintained on diets of different caloric densities. Following saline or insulin injections, food intake was measured every two hours for six hours or food was withheld for six hours until recovery of normo-glycemia and total intake was measured at seven and eight hours post-injection. Additionally, levels of plasma metabolic fuels, liver glycogen and stomach contents were measured following saline and insulin injections. Animals in both the continuous and delayed access conditions consumed the same number of calories following injections of insulin. Similarly, the increases in intake relative to saline baseline conditions were comparable across diet groups in both conditions although animals tested in the delayed access paradigm were less variable in their response. Changes in levels of metabolic fuels, stomach contents and liver glycogen were found to be consistent with the known effects of insulin and counter-regulatory responses to the induced hypoglycemia.
对维持不同热量密度饮食的雄性大鼠注射胰岛素后的热量摄入情况进行了研究。注射生理盐水或胰岛素后，每两小时测量一次食物摄入量，持续六小时，或者禁食六小时，直到血糖恢复正常，并在注射后七小时和八小时测量总摄入量。此外，在注射生理盐水和胰岛素后，还测量了血浆代谢燃料、肝糖原和胃内容物的水平。在连续获取和延迟获取条件下的动物，注射胰岛素后消耗的卡路里数量相同。同样，在两种条件下，相对于生理盐水基线条件，各饮食组的摄入量增加情况相当，尽管在延迟获取模式下测试的动物反应变异性较小。发现代谢燃料、胃内容物和肝糖原水平的变化与胰岛素的已知作用以及对诱导性低血糖的反调节反应一致。
