Masur H, Cheigh J S, Stubenbord W T
Rev Infect Dis. 1982 Nov-Dec;4(6):1208-19. doi: 10.1093/clinids/4.6.1208.
The spectrum of infectious complications during the first six months after 101 consecutive renal transplants was examined. The most common sites of infection were the lungs, the urinary tract, and the surgical incision. The causative organisms were similar to those in nonimmunosuppressed postsurgical patients. The infections were usually recognized readily by routine clinical examination and responded promptly to antibacterial therapy. Three patients developed opportunistic infection. No patient died as a result of infection. As at several other institutions in recent years, a declining frequency of serious or opportunistic infection in these immunosuppressed patients was noted. However, the results of this study differed markedly from recently reported data which emphasize the importance of overt cytomegaloviral disease as a cause of morbidity and as a factor predisposing to serious--often fatal--superinfection. These differences may be related to the immunosuppressive agents used and certainly have important implications for diagnostic and therapeutic management.
对连续101例肾移植术后头6个月内感染并发症的范围进行了检查。最常见的感染部位是肺部、尿路和手术切口。致病微生物与非免疫抑制的术后患者相似。这些感染通常通过常规临床检查很容易被识别，并对抗菌治疗迅速产生反应。3例患者发生机会性感染。没有患者因感染死亡。与近年来其他几家机构一样，注意到这些免疫抑制患者中严重或机会性感染的频率在下降。然而，本研究结果与最近报道的数据明显不同，后者强调显性巨细胞病毒病作为发病原因和导致严重（通常是致命的）重叠感染的一个因素的重要性。这些差异可能与所使用的免疫抑制剂有关，并且肯定对诊断和治疗管理具有重要意义。
