Lawler S D
Semin Hematol. 1982 Oct;19(4):257-72.
The review deals with technical considerations in relation to culturing and studying the chromosomes of leukemic cells. Specific and non-random chromosomal changes are described by the historic approach. Then follows a description of the application of chromosomal studies to diagnosis, progress and followup in the chronic and acute leukemias. A section is devoted to the application of chromosomal studies in bone-marrow transplantation. Finally, lines of research for leukemia using a genetic approach are suggested.
本综述涉及白血病细胞染色体培养和研究的技术考量。采用传统方法描述了特定的、非随机的染色体变化。接着描述了染色体研究在慢性和急性白血病的诊断、病情进展及随访中的应用。有一部分专门介绍了染色体研究在骨髓移植中的应用。最后，提出了采用遗传学方法研究白血病的研究方向。
