Suvorov A P
Vopr Med Khim. 1982 Nov-Dec;28(6):81-3.
Distinct activation of alkaline and trypsinlike proteinases, leucine aminopeptidase as well as inhibition of the antitryptic activity (ATA) occurred in the area of impaired skin and in peripheral blood of patients with psoriasis as shown by clinico-laboratory examinations. These data suggest the epidermal origin of the substance inhibiting the enzymatic activity. After administration into animals of homogenates of impaired skin obtained from the patients an increase in BAEE-esterase activity and a decrease in the ATA were observed in blood serum. A reverse correlation was found between the ATA of parakeratotic layer and amount of eosinophils in peripheric blood.
临床实验室检查显示，银屑病患者受损皮肤区域和外周血中碱性蛋白酶、类胰蛋白酶、亮氨酸氨肽酶有明显激活，同时抗胰蛋白酶活性（ATA）受到抑制。这些数据提示抑制酶活性物质的表皮来源。将患者受损皮肤匀浆注入动物后，血清中BAEE酯酶活性增加，ATA降低。角化不全层的ATA与外周血嗜酸性粒细胞数量呈负相关。
