Duzman E, Quinn C A, Warman A, Warman R
Acta Ophthalmol (Copenh). 1982 Aug;60(4):613-21. doi: 10.1111/j.1755-3768.1982.tb00608.x.
A one-month crossover trial comparing Piloplex 3.4% b.i.d. with pilocarpine 2.0% q.i.d. was conducted to compare the effectiveness of the 2 drugs in reducing the intraocular pressure of ocular hypertensive and open-angle glaucoma in subjects previously controlled with pilocarpine 2.0%. For both groups the mean IOP increased slightly from baseline with pilocarpine and decreased significantly from baseline with Piloplex. The side effects of both treatments were minor. Piloplex and pilocarpine treatment were both associated with eye dryness; Piloplex was associated with lacrimation in 2 subjects. This controlled study showed that Piloplex 3.4% b.i.d. was more effective than pilocarpine 2% q.i.d. in lowering intraocular pressure.
进行了一项为期一个月的交叉试验，比较每日两次使用3.4%的匹罗卡品与每日四次使用2.0%的毛果芸香碱，以比较这两种药物在降低曾用2.0%毛果芸香碱控制病情的高眼压症和开角型青光眼患者眼压方面的有效性。两组患者使用毛果芸香碱后平均眼压均较基线水平略有升高，而使用匹罗卡品后平均眼压较基线水平显著降低。两种治疗方法的副作用均较小。匹罗卡品和匹罗卡品治疗均与眼干有关；匹罗卡品使2名受试者出现流泪症状。这项对照研究表明，每日两次使用3.4%的匹罗卡品在降低眼压方面比每日四次使用2%的毛果芸香碱更有效。
