Høvding G, Aasved H
Department of Ophthalmology, University of Bergen, Norway.
Acta Ophthalmol (Copenh). 1987 Oct;65(5):594-601. doi: 10.1111/j.1755-3768.1987.tb07048.x.
The effect of a newly developed ophthalmic solution containing both 0.5% timolol and 2% resp. 4% pilocarpine was compared with that of timolol 0.5% eye drops alone in 93 patients with manifest simple or capsular glaucoma or ocular hypertension. The medications were administered twice daily. The absolute additive effect of pilocarpine was small, although the combined solutions caused a statistically significantly greater reduction of the intraocular pressure than that achieved by timolol alone. This additional effect appeared to last at least 12 h. The effect of the test solutions containing 2% resp. 4% pilocarpine was very similar. Apart from the well-known effects of the pilocarpine-induced miosis, the combined test medications were generally well tolerated.
在93例明显的单纯性或囊膜性青光眼或高眼压症患者中，将一种新开发的含有0.5%噻吗洛尔和2%及4%毛果芸香碱的眼科溶液的效果与单独使用0.5%噻吗洛尔滴眼液的效果进行了比较。药物每日给药两次。毛果芸香碱的绝对相加作用较小，尽管联合溶液导致眼压降低在统计学上显著大于单独使用噻吗洛尔所达到的降低幅度。这种额外作用似乎至少持续12小时。含有2%及4%毛果芸香碱的测试溶液的效果非常相似。除了毛果芸香碱引起的瞳孔缩小的众所周知的作用外，联合测试药物总体耐受性良好。
