Mazor Z, Ticho U, Rehany U, Rose L
Br J Ophthalmol. 1979 Jan;63(1):48-51. doi: 10.1136/bjo.63.1.48.
Induced accommodation and changes in vision (distance and near) were measured monocularly and binocularly in 9 young healthy volunteers in a double blind study after administering to them pilocarpine hydrochloride 4%, Piloplex 3.4, and saline eye drop instillations. Piloplex 3.4, a new long-acting pilocarpine polymer salt, and pilocarpine hydrochloride 4% (both contain equal amounts of pilocarpine-3.4%) induced changes in vision and accommodation. These changes were greater with pilocarpine hydrochloride than with Piloplex. The maximum changes occurred half an hour after instillation and the effect vanished after an additional period up to 3 hours. The changes were greater when measured monocularly than binocularly. Piloplex initiates a prolonged hypotensive effect which lasts for 12 hours. Patients with glaucoma are thus able to use Piloplex on a twice-daily schedule. Consequently, visual disturbances occur only once a day in contrast to pilocarpine hydrochloride given 4 times a day, which induces 3 visual disturbances during the day.
在一项双盲研究中，对9名年轻健康志愿者单眼和双眼测量了使用4%盐酸毛果芸香碱、3.4%匹罗普乐克斯（Piloplex）和生理盐水滴眼剂滴入后诱发的调节及视力变化（远视力和近视力）。3.4%匹罗普乐克斯是一种新型长效毛果芸香碱聚合物盐，4%盐酸毛果芸香碱（二者含等量的3.4%毛果芸香碱）均能引起视力和调节变化。盐酸毛果芸香碱引起的这些变化比匹罗普乐克斯更大。最大变化出现在滴入后半小时，额外3小时后效果消失。单眼测量时的变化比双眼测量时更大。匹罗普乐克斯可引发持续12小时的长时间降压作用。因此，青光眼患者能够每天使用两次匹罗普乐克斯。结果，与每天给药4次的盐酸毛果芸香碱相比，视觉干扰每天仅出现一次，后者在一天中会诱发3次视觉干扰。
