Hand M S, Phillips R W, Chandrasena L G, Cleek J L
Adv Shock Res. 1981;6:131-40.
Chronic hepatic artery and portal vein flowcuffs, in concert with hepatic vein and portal vein catheters, were placed in a Yucatan miniature pig. One week following surgery an endotoxin infusion was initiated. During endotoxemia there was a period of reverse portal vein flow while hepatic artery flow continued. This aberration resulted in unusual portal vein substrate and hormone concentrations. As endotoxemia progressed, the pig became hypoglycemic and hyperlactemic. Specific activity of [6-3H] - glucose was constant during developmental hypoglycemia, while insulin secretion rate was minimal indicating a significant endotoxin-induced, insulin-like activity. Hepatocytes isolated from the pig's liver at termination had inhibited gluconeogenic capacity.
在一只尤卡坦小型猪身上放置了慢性肝动脉和门静脉血流袖带，并配合肝静脉和门静脉导管。术后一周开始进行内毒素输注。在内毒素血症期间，门静脉血流出现了一段时间的逆流，而肝动脉血流持续。这种异常导致门静脉底物和激素浓度异常。随着内毒素血症的进展，猪出现了低血糖和高乳酸血症。在低血糖发展过程中，[6-³H]-葡萄糖的比活性保持恒定，而胰岛素分泌率最低，表明存在显著的内毒素诱导的类胰岛素活性。在实验结束时从猪肝脏分离出的肝细胞的糖异生能力受到抑制。
