Spangler R S, Phillips R W
Horm Metab Res. 1981 Dec;13(12):669-72. doi: 10.1055/s-2007-1019371.
A group of Yucatan miniature swine exhibiting impaired glucose tolerance (Kq = .91 +/- .04), were examined with respect to their portal and hepatic vein insulin levels following a fasting intravenous glucose tolerance test. The majority of these animals (9 of 11) were found to exhibit the expected portal vein insulin deficiency. This deficiency was found to encompass all phases of the insulin response and was not limited to the acute secretory phase. The remaining two animals were found to have normal portal vein insulin concentrations while exhibiting reduced hepatic vein insulin levels, and impaired glucose tolerance. An excessive rate of hepatic insulin extraction is proposed to explain the etiology of the insulin deficiency and glucose intolerance observed in these latter two animals.
一组表现出葡萄糖耐量受损（Kq = 0.91 ± 0.04）的尤卡坦小型猪，在进行空腹静脉葡萄糖耐量试验后，对其门静脉和肝静脉胰岛素水平进行了检测。这些动物中的大多数（11只中的9只）被发现表现出预期的门静脉胰岛素缺乏。这种缺乏被发现涵盖胰岛素反应的所有阶段，并且不限于急性分泌阶段。其余两只动物被发现门静脉胰岛素浓度正常，而肝静脉胰岛素水平降低，且葡萄糖耐量受损。有人提出肝脏胰岛素提取率过高可解释后两只动物中观察到的胰岛素缺乏和葡萄糖不耐受的病因。
