Kimura R S
Am J Otolaryngol. 1982 Nov-Dec;3(6):447-51. doi: 10.1016/s0196-0709(82)80023-9.
Endolymphatic hydrops in the animal can be produced by various methods. The most promising is obliteration of the endolymphatic duct in the guinea pig. The extent of hydrops is similar to that of Ménière's disease specimens, but the animals are asymptomatic. A better model, utilizing a less invasive method and having the ability to elicit episodic vestibular symptoms, is needed. There is a reasonable doubt that one of the causes for Ménière's disease lies in the abnormal endolymphatic duct and sac. A wide ablation of such pathologic tissue may provide additional pathogenetic information.
动物体内的内淋巴积水可通过多种方法产生。最有前景的方法是在豚鼠身上闭塞内淋巴管。积水程度与梅尼埃病标本相似，但动物没有症状。因此需要一种更好的模型，该模型采用侵入性较小的方法，并有能力引发发作性前庭症状。梅尼埃病的病因之一在于内淋巴管和内淋巴囊异常，这一点存在合理疑问。广泛切除此类病理组织可能会提供更多的发病机制信息。
