Harrison R V, Orsulakova-Meyer zum Gottesberge A, Erre J P, Mori N, Aran J M, Morgenstern C, Tavartkiladze G A
Hear Res. 1984 Apr;14(1):85-91. doi: 10.1016/0378-5955(84)90071-6.
Experimental endolymphatic hydrops was induced in guinea pigs by obliteration of the endolymphatic sac and duct. From 3 to 24 months after this operation, cochlear action potential (AP) audiograms and AP tuning curves were measured. The purpose of this study was to establish parallels, if any, between this supposed animal model of Menière's disease and the auditory symptoms of the disease in man. In some animals, low and middle frequency AP threshold elevations were observed whilst higher frequency regions maintained normal sensitivity. Other animals developed flat or very gradually sloping AP audiograms. These patterns are qualitatively similar to those found clinically in Menière's disease. AP tuning curves measured in frequency regions of threshold elevation indicated a deterioration of cochlear frequency selectivity; psychophysical and electrocochleographic studies demonstrate related changes in Menière's patients. One animal exhibited modifications in AP thresholds and tuning as a result of glycerol administration. These observations improve our confidence in the validity of this animal model for further studies of the pathophysiology of Menière's disease.
通过闭塞内淋巴囊和导管在豚鼠中诱发实验性内淋巴积水。在该手术后3至24个月，测量耳蜗动作电位（AP）听力图和AP调谐曲线。本研究的目的是确定这种假定的梅尼埃病动物模型与人类疾病的听觉症状之间是否存在相似之处。在一些动物中，观察到低频和中频AP阈值升高，而高频区域保持正常敏感性。其他动物则出现平坦或非常逐渐倾斜的AP听力图。这些模式在质量上与梅尼埃病临床发现的模式相似。在阈值升高的频率区域测量的AP调谐曲线表明耳蜗频率选择性恶化；心理物理学和电耳蜗图研究表明梅尼埃病患者有相关变化。一只动物由于甘油给药而表现出AP阈值和调谐的改变。这些观察结果增强了我们对该动物模型用于进一步研究梅尼埃病病理生理学有效性的信心。
