Harrison R V, Prijs V F
Hear Res. 1984 Apr;14(1):79-84. doi: 10.1016/0378-5955(84)90070-4.
Some cochlear fibre response properties have been measured in two GPs approximately one year after induction of endolymphatic hydrops (by surgical obliteration of the endolymphatic sac and duct). These animals are considered as models of the effects of hydrops in Menière's disease, and the purpose of the study was to examine any modifications of fibre response properties which may underly auditory symptoms of the disease in man. Neurones towards more apical cochlear regions (with low characteristic frequencies) showed the greatest deterioration in tuning properties; on average, in the 1-6 kHz range, Q10dB values were reduced by a factor of two compared with normal animals. Discharge rate versus intensity functions of such units were abnormally steep, with dynamic ranges reduced by 10-20 dB. Towards higher frequency regions neurone response properties showed less deterioration (contrasting with many other types of cochlear pathology where, in general, the high frequency basal region exhibits greatest vulnerability). We have also observed in a few units an abnormal bursting in both spontaneous and driven discharge. Interspike intervals during burst are less than 1 ms (within relative refractory period). These findings are related to the auditory symptoms of Menière's disease, in particular, poor frequency selectivity, loudness recruitment and tinnitus.
在内淋巴积水诱导（通过手术闭塞内淋巴囊和导管）约一年后，在两只豚鼠中测量了一些耳蜗纤维的反应特性。这些动物被视为梅尼埃病中积水影响的模型，该研究的目的是检查纤维反应特性的任何改变，这些改变可能是人类该疾病听觉症状的基础。朝向耳蜗更顶端区域（特征频率较低）的神经元在调谐特性方面表现出最大程度的恶化；平均而言，在1-6千赫范围内，与正常动物相比，Q10dB值降低了一半。此类单元的放电率与强度函数异常陡峭，动态范围降低了10-20分贝。朝向高频区域，神经元反应特性的恶化程度较小（这与许多其他类型的耳蜗病理学形成对比，在其他类型中，一般高频基底区域表现出最大的脆弱性）。我们还在少数单元中观察到自发放电和驱动放电中均出现异常爆发。爆发期间的峰间间隔小于1毫秒（处于相对不应期内）。这些发现与梅尼埃病的听觉症状有关，特别是频率选择性差、响度重振和耳鸣。
