Leithner C, Sinzinger H, Pohanka E, Schwarz M, Syré G, Höfer R
Acta Med Austriaca. 1982;9(5-6):185-9.
Indium 111 (111In) labelled autologous platelets were used in the diagnostic observation of patients after renal transplantation. 75 patients were collected in 3 groups of 25 cases each. The first group consisted of patients who were examined during the first 4 weeks after transplantation. Group 2 were patients suffering from histologically proved chronic graft rejection. The 3rd group included cases with good and stable transplant function tested at least 9 months after transplantation. By means of a computerized static study the transplants were examined under the gamma-camera concerning a platelet trapping. Thereby a platelet-uptake-index (PUI) was calculated and compared with the platelet half-life-time (t1/2). This diagnostic method turned out to be suitable for early diagnosis of acute graft rejection. Hereby the PUI increased from 1.13 +/- 0.11 to 1.74 +/- 0.17. The further course of rejection episode manifested itself in corresponding changes of PUI. In irreversible rejections the PUI stayed in the high range or increased further. On the other hand reversible graft rejections showed a reduction of PUI, however, in the most cases not to the original basic level. The platelet t1/2 exhibited a strong negative correlation with PUI. Cases suffering from chronic transplant rejection revealed significantly higher platelet trapping by the graft than patients with good and stable transplant function.
铟111（¹¹¹In）标记的自体血小板被用于肾移植患者的诊断观察。共收集75例患者，分为3组，每组25例。第一组为移植后前4周内接受检查的患者。第二组为经组织学证实患有慢性移植排斥反应的患者。第三组包括移植后至少9个月移植功能良好且稳定的病例。通过计算机静态研究，在γ相机下检查移植肾的血小板捕获情况。由此计算出血小板摄取指数（PUI），并与血小板半衰期（t1/2）进行比较。这种诊断方法被证明适用于急性移植排斥反应的早期诊断。在此过程中，PUI从1.13±0.11增加到1.74±0.17。排斥反应的进一步发展表现为PUI的相应变化。在不可逆排斥反应中，PUI保持在高水平或进一步升高。另一方面，可逆性移植排斥反应表现为PUI降低，但在大多数情况下未降至原始基线水平。血小板t1/2与PUI呈强烈负相关。患有慢性移植排斥反应的病例显示，移植肾捕获的血小板明显高于移植功能良好且稳定的患者。
