Rosenwasser L J
Clin Immunol Rev. 1981;1(2):311-35.
Immunologic responses to insulin can be manifested by both laboratory animals immunized with insulin as a known modifiable model antigen and by patients receiving heterologous insulin as a mainstay of therapy for insulin dependent diabetes mellitus. The use of purified insulin as a model antigen for the study of cellular interactions, T cell antigen recognition, and the mechanism and specificity of Ir gene action in experimental animals has given us great insight into the potential workings of these complex functions. In humans with IDDM, immune cofactors may play a role in both the pathogenesis of disease as well as the obvious complications of therapy. Intense study of cellular, genetic, biochemical, and immunologic parameters in these patients with IDDM may provide us with unique insights into the complex regulatory interactions between the immunologic and endocrine-metabolic systems.
对胰岛素的免疫反应可在以胰岛素作为已知可修饰模型抗原进行免疫的实验动物以及接受异种胰岛素作为胰岛素依赖型糖尿病主要治疗手段的患者中表现出来。将纯化胰岛素用作实验动物中细胞相互作用、T细胞抗原识别以及Ir基因作用机制和特异性研究的模型抗原，使我们对这些复杂功能的潜在运作有了深入了解。在胰岛素依赖型糖尿病患者中，免疫辅助因子可能在疾病发病机制以及治疗的明显并发症中都发挥作用。对这些胰岛素依赖型糖尿病患者的细胞、遗传、生化和免疫参数进行深入研究，可能会为我们提供关于免疫和内分泌代谢系统之间复杂调节相互作用的独特见解。
