Chaignon M, Guelpa G, Lucsko M, Guédon J
Nouv Presse Med. 1982 Dec 11;11(50):3717-21.
Numerous studies have recently been devoted to the effects of prostaglandins on blood vessels. Prostacyclin (PGI2) produces relaxation of vascular smooth muscles, thereby contributing, with other vasoactive substances, to the regulation of general and local haemodynamics. Moreover, it would appear that the effects of some risk factors in atherosclerosis are mediated, at least partly, by changes in prostaglandin production. The potent vasodilator action of prostacyclin has been confirmed in man and has been investigated in some pathological conditions, such as lower limb arteriopathy, malignant arterial hypertension and coronary artery disease. The vascular effects of many therapeutic drugs are now known to be associated with their action on the biosynthesis of prostaglandins. Further studies are required to determine the role of prostaglandins, especially prostacyclin, in the pathophysiology, prevention and treatment of vascular diseases.
最近有许多研究致力于探讨前列腺素对血管的影响。前列环素（PGI2）可使血管平滑肌舒张，从而与其他血管活性物质一起参与全身和局部血流动力学的调节。此外，动脉粥样硬化某些危险因素的作用似乎至少部分是由前列腺素生成的变化介导的。前列环素强大的血管舒张作用已在人体得到证实，并已在一些病理状况下进行了研究，如下肢动脉病变、恶性动脉高血压和冠状动脉疾病。现已知道许多治疗药物的血管效应与其对前列腺素生物合成的作用有关。需要进一步研究以确定前列腺素，尤其是前列环素，在血管疾病的病理生理学、预防和治疗中的作用。
