Pope L M, Cole G T
Scan Electron Microsc. 1982(Pt 4):1667-76.
Studies of host-parasite interactions involved in gastrointestinal and systemic candidosis have been hampered by the lack of suitable animal models which mimic the disease in humans. The infant mouse has proved to be a realistic and useful model for studies of candidosis. Oral-intragastric inoculation of infants leads to systemic spread and lethality without use of compromising procedures. Not all species or strains of Candida inoculated via this route are lethal to the infant mouse nor do they demonstrate the same degree of persistence. Certain strains of C. albicans display long term colonization of the GI tract and such persistently infected mice resemble the situation in humans with C. albicans as a common, but quantitatively minor, component of the flora of the alimentary tract. The infant mouse model thereby has the potential of providing an excellent tool for experimental modification of the GI flora which reflects the situation in debilitated and compromised humans that leads to alterations of the host-pathogen balance favoring development of candidosis. This paper provides additional evidence for the validity of the infant mouse model for investigations of gastrointestinal and systemic candidosis by comparing colonization and systemic spread of two strains of C. albicans (Ca 30 and NS 33), C. guilliermondii, Saccharyomyces cerevisiae and latex beads.
由于缺乏能模拟人类疾病的合适动物模型，胃肠道和全身性念珠菌病中宿主 - 寄生虫相互作用的研究受到了阻碍。事实证明，幼鼠是研究念珠菌病的一种现实且有用的模型。对幼鼠进行口服 - 胃内接种会导致全身扩散和致死，而无需采用损害机体的操作。并非所有通过这种途径接种的念珠菌物种或菌株对幼鼠都是致死性的，它们也未表现出相同程度的持续性。某些白色念珠菌菌株会在胃肠道长期定植，此类持续感染的小鼠类似于人类的情况，即白色念珠菌是消化道菌群中常见但数量较少的组成部分。幼鼠模型因此有潜力为实验性改变胃肠道菌群提供一个出色的工具，这种改变反映了衰弱和机体受损的人类体内的情况，而这种情况会导致宿主 - 病原体平衡发生改变，有利于念珠菌病的发展。本文通过比较两株白色念珠菌（Ca 30和NS 33）、季也蒙念珠菌、酿酒酵母和乳胶珠的定植及全身扩散情况，为幼鼠模型用于胃肠道和全身性念珠菌病研究的有效性提供了更多证据。
