Camarasa J G, Moragas J M
Med Cutan Ibero Lat Am. 1982;10(5):339-42.
Ketotifen inhibits the Ca++ pass through the mastocyte and basophil membrane. So inhibit histamine and S. R. S. A. liberation. Results in the treatment with Ketotifen of 36 cases of chronic Urticaria are exposed. Patients between ten and fifty years old, and with symptoms chronicity during from two until ten years, were studied. Chronic cases of unknown etiology, cholinergic urticaria, salicylates urticaria, urticaria by pressure, local heat urticaria and chronic dermographism were treated. Results were hopeful. Especially in patients with cholinergic urticaria, urticaria by heat, salicylates urticaria and strong idiopathic dermographism.
酮替芬可抑制钙离子通过肥大细胞和嗜碱性粒细胞膜。从而抑制组胺和慢反应物质A的释放。本文报道了用酮替芬治疗36例慢性荨麻疹的结果。研究对象为年龄在10岁至50岁之间、症状持续2至10年的患者。对病因不明的慢性病例、胆碱能性荨麻疹、水杨酸类荨麻疹、压力性荨麻疹、局部热性荨麻疹和慢性皮肤划痕症进行了治疗。结果令人满意。特别是对于胆碱能性荨麻疹、热性荨麻疹、水杨酸类荨麻疹和严重特发性皮肤划痕症患者。
