Cap J P, Schwanitz H J, Czarnetzki B M
Hautarzt. 1985 Sep;36(9):509-11.
Forty patients with urticaria, 13 with cholinergic urticaria, 22 with urticaria factitia, and 5 with both types of urticaria, were treated with ketotifen or placebo in a double-blind crossover study. Five patients dropped out, one because of excessive weight gain. In 23 of 24 patients with urticaria factitia, ketotifen caused a marked reduction of wealing and pruritus. In contrast, only 62% of the patients with cholinergic urticaria noticed a reduction of wealing, and 69% had reduced itching. Ketotifen caused few side effects, the most frequent one being mild tiredness in 9% of the patients. The beneficial effect of ketotifen in urticaria factitia and cholinergic urticaria may be due to its ability to reduce the liberation and the effectiveness of mast cell mediators.
在一项双盲交叉研究中，40名荨麻疹患者、13名胆碱能性荨麻疹患者、22名人工性荨麻疹患者以及5名同时患有这两种荨麻疹的患者接受了酮替芬或安慰剂治疗。5名患者退出研究，其中1名是因为体重过度增加。在24名人工性荨麻疹患者中，有23名患者使用酮替芬后风团和瘙痒明显减轻。相比之下，胆碱能性荨麻疹患者中只有62%的人发现风团有所减轻，69%的人瘙痒有所减轻。酮替芬的副作用很少，最常见的是9%的患者出现轻度疲劳。酮替芬对人工性荨麻疹和胆碱能性荨麻疹的有益作用可能是由于其能够减少肥大细胞介质的释放及其作用效果。
