Frisch B, Bartl R, Burkhardt R
Haematologia (Budap). 1982;15(3):245-85.
Bone marrow biopsies are now employed in the investigation of many disorders in haematology, oncology and internal medicine. This review provides a survey of the recent literature and a summary of observations made on undecalcified bone marrow biopsies embedded in plastic. The conditions investigated include osteopathies, myelopathies, haematologic and non-haematologic malignancies in the bone marrow. The interrelationship and interdependence of bone and bone marrow have been emphasized, and examples of the effects of diseases of bone on marrow, and of disturbancies of marrow function on bone, have been given. In the myelo- and lympho-proliferative disorders bone marrow biopsies contribute to diagnostic evaluation and classification, as well as to provide factors of prognostic significance. In the investigation of patients with solid tumours bone marrow biopsy may detect metastases in 20 per cent (bronchus), 35 per cent (prostate), 40 per cent (breast), to 80 per cent (unknown primaries) of the patients. Bone marrow biopsy constitutes an additional investigative parameter capable of providing valuable information in many different clinical situations.
骨髓活检目前用于血液学、肿瘤学和内科许多疾病的检查。本综述对近期文献进行了概述，并总结了对包埋于塑料中的未脱钙骨髓活检标本的观察结果。所研究的情况包括骨病、骨髓病、骨髓中的血液系统和非血液系统恶性肿瘤。强调了骨与骨髓的相互关系和相互依存性，并列举了骨病对骨髓的影响以及骨髓功能紊乱对骨的影响的实例。在骨髓增殖性和淋巴细胞增殖性疾病中，骨髓活检有助于诊断评估和分类，并提供具有预后意义的因素。在实体瘤患者的检查中，骨髓活检在20%（支气管癌）、35%（前列腺癌）、40%（乳腺癌）至80%（原发灶不明）的患者中可检测到转移灶。骨髓活检是一项额外的检查参数，能够在许多不同的临床情况下提供有价值的信息。
