Jones R L, McDermott K, Drexler A, Niquette W S, Peterson C M
Diabetes Care. 1982 May-Jun;5 Suppl 1:102-3.
Besides the obvious toxicity of overdosage and hypoglycemia, insulin administration may also be complicated by a variety of local cutaneous reactions and systemic allergic complications. Although these responses are by no means universal among patients injecting insulin, they may pose significant clinical problems. This is particularly true for the localized skin reactions such as lipoatrophy and the systemic insulin allergy leading to insulin resistance. Most commercially available insulin preparations are extracts of pork or beef pancreas. One approach to reducing insulin complications is to improve the homogeneity of commercial preparations by further purification, which has been afforded by recent technology. A priori, the preparations most resembling human insulin with the fewest contaminants should provide the optimal therapy for diabetic patients. Whether this will prove to be the case remains to be documented.
除了明显的过量用药毒性和低血糖外，注射胰岛素还可能并发各种局部皮肤反应和全身性过敏并发症。尽管这些反应在注射胰岛素的患者中并非普遍存在，但可能会引发严重的临床问题。对于局部皮肤反应（如脂肪萎缩）和导致胰岛素抵抗的全身性胰岛素过敏来说尤其如此。大多数市售胰岛素制剂是从猪或牛胰腺中提取的。减少胰岛素并发症的一种方法是通过进一步纯化来提高商业制剂的同质性，这是最近的技术所实现的。从理论上讲，最接近人胰岛素且污染物最少的制剂应该为糖尿病患者提供最佳治疗。这是否属实仍有待证实。
