Oh H K, Provenzano R, Hendrix J, el-Nachef M W
Division of Nephrology, St. John Hospital and Medical Center, Transplant Specialty Center, Detroit, MI 48236, USA.
Clin Transplant. 1998 Dec;12(6):593-5.
Clinically significant immunological reactions to exogenous insulin are classified as local or generalized. Most of the insulin allergies are local reactions which usually improve or resolve spontaneously. Generalized allergic reactions to insulin range in severity from simple urticaria to life-threatening anaphylaxis. Most of the allergic reactions to exogenous insulin are antibody-mediated reactions to antigens such as zinc, protamine, non-insulin proteins, and aggregates of insulin molecules as well as animal antigens. Immunologic reactions to endogenous insulin usually result in insulin resistance. Herein, we report a case in which systemic insulin allergy was intractable, thus requiring a pancreas transplantation which is the first of its case according to the International Pancreas Transplant Registry/United Network for Organ Sharing (IPTR/UNOS) Registry.
对外源性胰岛素的具有临床意义的免疫反应分为局部反应或全身性反应。大多数胰岛素过敏是局部反应，通常会自行改善或消退。胰岛素的全身性过敏反应严重程度不一，从单纯性荨麻疹到危及生命的过敏反应。大多数对外源性胰岛素的过敏反应是抗体介导的对抗原的反应，这些抗原包括锌、鱼精蛋白、非胰岛素蛋白、胰岛素分子聚集体以及动物抗原。对内源性胰岛素的免疫反应通常会导致胰岛素抵抗。在此，我们报告一例全身性胰岛素过敏难以治疗的病例，因此需要进行胰腺移植，根据国际胰腺移植登记处/器官共享联合网络（IPTR/UNOS）登记处的记录，这是首例此类病例。
