[Allergy to insulin].

Allergic reactions to insulin have been noted within a few years following the completion of therapy. Allergy to insulin may be manifested by discrete local skin reactions (the majority of diabetics) or generalized reaction (rarely). Allergy to insulin may be produced by: immunogenicity of the commercial animal insulin preparations, low purity of insulins, different pattern of therapy with insulin, and genetic factors. The treatment of allergy to insulin consists of a proper injection technique and optimum choice of insulin preparation. In case of generalized allergic reactions desensitization is a therapy of choice. Antihistamine agents and corticosteroids may be helpful in some cases.