Renner R, Vocke K, Hepp K D
Diabetes Care. 1982 Nov-Dec;5 Suppl 2:53-6. doi: 10.2337/diacare.5.2.s53.
After 2 wk of good control 9 type I diabetic patients were hospitalized and treated in a randomized fashion with different human insulin mixtures (regular: NPH), containing 10, 15, or 20% regular insulin. In the case of the 15:85% mixture, mean blood glucose was found to be in the range of 70-150 mg/dl. Significant differences occurred at certain time points between the curves obtained with the 10:90% and the 15:85% mixtures, and the 10:90% and the 20:80% preparations, respectively. Prolongation of the interval between hormone injection and start of breakfast from 30 to 45 min abolished the postprandial glucose excursion in the 15:85% and the 20:80% mixture, but not the 10:90% mixture.
在经过2周的良好血糖控制后，9名I型糖尿病患者住院，并以随机方式接受不同比例的人胰岛素混合制剂（正规胰岛素：中效胰岛素）治疗，其中正规胰岛素含量分别为10%、15%或20%。对于15:85%的混合制剂，发现平均血糖值在70 - 150mg/dl范围内。分别在某些时间点，10:90%与15:85%混合制剂所得曲线之间，以及10:90%与20:80%制剂所得曲线之间出现了显著差异。将激素注射与早餐开始之间的间隔从30分钟延长至45分钟，消除了15:85%和20:80%混合制剂的餐后血糖波动，但10:90%混合制剂未受影响。
