Marre M, Tabbi-Anneni A, Tabbi-Anneni H, Assan R
Diabetes Care. 1982 Nov-Dec;5 Suppl 2:63-6. doi: 10.2337/diacare.5.2.s63.
The hypoglycemic potencies of human insulin (recombinant DNA) and bovine NPH insulin were compared in insulin-dependent diabetic subjects. The same dosages of the two preparations were alternately injected, for two successive 5-day periods, on a twice-a-day schedule. Blood glucose profiles were monitored by finger pricking 6 times/day. Slight but significant differences in glucose time appeared, suggesting that human NPH insulin acts faster than bovine NPH, and for a shorter time.
在胰岛素依赖型糖尿病患者中比较了人胰岛素（重组DNA）和牛NPH胰岛素的降血糖效力。两种制剂以相同剂量，每天两次，交替注射，连续两个5天周期。通过每天6次手指采血监测血糖曲线。血糖时间出现了轻微但显著的差异，表明人NPH胰岛素比牛NPH胰岛素起效更快，作用时间更短。
