Mirouze J, Monnier L, Richard J L, Gancel A, Soua K B
Diabetes Care. 1982 Nov-Dec;5 Suppl 2:60-2. doi: 10.2337/diacare.5.2.s60.
Continuous blood glucose monitoring in six insulin-dependent diabetic patients shows that the biologic action of NPH human insulin (recombinant DNA) and pork insulin is similar. Nevertheless, the activity of NPH human insulin seems faster and more pronounced since minimal glycemia is lower and more rapidly reached after human insulin. The speed of glycemic increase is slightly lower and the decrease is faster with NPH human insulin; thus the area under the NPH human insulin-induced glycemic curve is less wide, but differences are not significant. Our data favor a faster and more potent effect of NPH human insulin.
对6例胰岛素依赖型糖尿病患者进行的连续血糖监测显示，NPH人胰岛素（重组DNA）和猪胰岛素的生物学作用相似。然而，NPH人胰岛素的活性似乎更快且更显著，因为在使用人胰岛素后，最低血糖水平更低且达到得更快。使用NPH人胰岛素时，血糖升高速度略低，下降速度更快；因此，NPH人胰岛素诱导的血糖曲线下面积较窄，但差异不显著。我们的数据支持NPH人胰岛素具有更快且更强效的作用。
