Greene R W, Carpenter D O
Division of Laboratories and Research, New York State Department of Health, Albany 12201.
Cell Mol Neurobiol. 1981 Dec;1(4):401-5. doi: 10.1007/BF00716274.
Acetylcholine (ACh) responses were elicited by ionophoresis from neurons, located in the medial pontine reticular formation, which were antidromically identified as having axons projecting in the reticulospinal tracts. Most neurons were silent at rest and could be caused to discharge at a regular, slow rate by a constant application of glutamate. ACh altered this slow rate of firing in 28 of 29 cells but showed three different patterns of effect: approximately one-third were excited, one-third were inhibited, and one-third showed biphasic inhibition-excitation. The ACh responses were not sensitive to atropine. These observations suggest that reticulospinal neurons have ACh receptors mediating both inhibition and excitation, perhaps located on different portions of the same neuron.
通过离子电泳从位于脑桥内侧网状结构的神经元诱发乙酰胆碱（ACh）反应，这些神经元经逆向鉴定为轴突投射到网状脊髓束。大多数神经元在静息时不活动，持续施加谷氨酸可使其以规律、缓慢的速率放电。乙酰胆碱改变了29个细胞中28个细胞的这种缓慢放电速率，但表现出三种不同的效应模式：约三分之一被兴奋，三分之一被抑制，三分之一表现出双相抑制-兴奋。乙酰胆碱反应对阿托品不敏感。这些观察结果表明，网状脊髓神经元具有介导抑制和兴奋的乙酰胆碱受体，可能位于同一神经元的不同部位。
