Kunkel S L, Zanetti M, Sapin C
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.
Am J Pathol. 1982 Aug;108(2):240-5.
The ability of specific prostaglandins to modulate the development of nephrotoxic serum nephritis (NSN) in rats has been examined. The nephrotoxicity of one intravenous injection of antibodies directed against rat glomerular basement membrane (GBM) was markedly suppressed by treatment with a stable analog of prostaglandin E1 (15-(S)-15-methyl PGE1; 15-M-PGE1). Prostaglandin E1 treatment was shown to suppress both glomerular hypercellularity and proteinuria, while the binding of specific antibody to the GBM was not altered. These studies indicate that certain prostaglandins may play an important role in the regulation of Type II immune reactions. Further investigations of the role of arachidonic acid products undoubtedly will provide valuable information regarding the modulation of tissue injury as a result of various inflammatory reactions.
已对特定前列腺素调节大鼠肾毒性血清肾炎（NSN）发展的能力进行了研究。静脉注射一次针对大鼠肾小球基底膜（GBM）的抗体所导致的肾毒性，通过用前列腺素E1的稳定类似物（15 -（S）-15 -甲基PGE1；15 - M - PGE1）进行治疗而得到显著抑制。结果表明，前列腺素E1治疗可同时抑制肾小球细胞增多和蛋白尿，而特异性抗体与GBM的结合并未改变。这些研究表明，某些前列腺素可能在II型免疫反应的调节中发挥重要作用。毫无疑问，对花生四烯酸产物作用的进一步研究将提供有关各种炎症反应所致组织损伤调节的有价值信息。
