碳酸酐酶同工酶测定：对“小于胎龄儿”诊断的辅助手段。
Carbonic anhydrase isoenzyme determination: An aid to the diagnosis of "small-for-date" infants.
作者信息
Mondrup M, Anker N, Christensen F
出版信息
Clin Chim Acta. 1980 Jan 15;100(2):107-12. doi: 10.1016/0009-8981(80)90071-6.
A specific and quantitative immunological method for the determination of human erythrocyte carbonic anhydrase isoenzymes B and C has been used to determine these enzymes in erythrocytes of umbilical cord blood. The investigations have shown a content of both isoenzymes less than a tenth of that in adults. The isoenzyme content correlated significantly with the estimated gestational age. The ratio between isoenzyme B and C rose with gestational age, reaching adult level at term. A group of 19 "small-for-date" infants had isoenzyme levels in the same range as normal full-term infants, significantly higher than the levels in the same range as normal full-term infants, significantly higher than the levels in truly premature infants. It is concluded that the determination of carbonic anhydrase isoenzymes is an aid in distinguishing "small-for-date" infants from the truly premature.
一种用于测定人红细胞碳酸酐酶同工酶B和C的特异性定量免疫方法已被用于测定脐带血红细胞中的这些酶。研究表明，两种同工酶的含量均不到成年人的十分之一。同工酶含量与估计的胎龄显著相关。同工酶B和C的比例随胎龄增加而上升，足月时达到成人水平。一组19名“小于胎龄”婴儿的同工酶水平与正常足月婴儿相同，明显高于真正早产儿的水平。结论是，碳酸酐酶同工酶的测定有助于区分“小于胎龄”婴儿和真正的早产儿。
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