Waxman A D, McKee D, Siemsen J K, Singer F R
AJR Am J Roentgenol. 1980 Feb;134(2):303-6. doi: 10.2214/ajr.134.2.303.
Calcitonin has been used in the treatment of Paget's disease of bone, and serum alkaline phosphatase level and 24 hr urinary hydroxyproline excretion have been used to follow therapeutic response. The radionuclide bone scan has been used as a visual indicator; however, there is some uncertainty as to its value in following changes in disease activity. Four patients with both serial technetium phosphate bone scans and serial gallium studies were studied. In each case the beneficial effect of calcitonin was demonstrated more accurately with gallium than with technetium diphosphonate. Since biochemical changes in Paget's disease are believed to be mediated at the cellular level and gallium uptake depends on cellular activity, it is proposed that gallium uptake is a more appropriate measure of the activity of Paget's disease than a noncellular marker such as a technetium-containing bone scan agent.
降钙素已被用于治疗骨Paget病，血清碱性磷酸酶水平和24小时尿羟脯氨酸排泄量已被用于跟踪治疗反应。放射性核素骨扫描已被用作一种视觉指标；然而，关于其在跟踪疾病活动变化方面的价值存在一些不确定性。对4例同时进行了系列磷酸锝骨扫描和系列镓研究的患者进行了研究。在每种情况下，与二膦酸锝相比，镓更准确地证明了降钙素的有益效果。由于骨Paget病的生化变化被认为是在细胞水平介导的，且镓摄取取决于细胞活性，因此有人提出，与含锝骨扫描剂等非细胞标记物相比，镓摄取是衡量骨Paget病活动度的更合适指标。
