Boudreau R J, Lisbona R, Hadjipavlou A
J Nucl Med. 1983 Oct;24(10):880-5.
Twenty-four symptomatic patients with symptoms of active Paget's disease of bone were evaluated, during the course of their therapy, a total of 71 times (24 baseline and 47 follow-up examinations) by serial alkaline phosphatase levels (AP), Tc-99m MDP bone scans, and radionuclide blood-flow studies. The flow study correlated with disease activity in all of the baseline studies and in at least 85% of the follow-up studies. In five patients (seven follow-up studies) the changes in local blood flow correctly anticipated the eventual rise or fall of AP. In comparison with the bone scan, the changes in blood flow preceded the bone-scan alterations or were more reliable indicators of disease activity in 12 of the 13 follow-up studies in which the results of the two examinations disagreed. We conclude that the radionuclide flow study provides useful additional clinical information in the management of Paget's disease.
对24例有活动性骨Paget病症状的患者在治疗过程中进行了评估，通过连续检测碱性磷酸酶水平（AP）、锝-99m亚甲基二膦酸盐（Tc-99m MDP）骨扫描和放射性核素血流研究，共进行了71次检查（24次基线检查和47次随访检查）。在所有基线研究以及至少85%的随访研究中，血流研究与疾病活动相关。在5例患者（7次随访研究）中，局部血流的变化正确地预测了AP最终的升高或降低。与骨扫描相比，在两项检查结果不一致的13次随访研究中的12次中，血流变化先于骨扫描改变，或者是疾病活动更可靠的指标。我们得出结论，放射性核素血流研究在Paget病的管理中提供了有用的额外临床信息。
