Sbarbaro J A, Catlin B J, Iseman M
Am Rev Respir Dis. 1980 Jan;121(1):172-4. doi: 10.1164/arrd.1980.121.1.172.
The long-term effectiveness of intermittent non-rifampin-containing regimens for the treatment of tuberculosis is demonstrated. The direct administration of 170 to 190 doses during an extended period of time (18 to 20 months) permits a 10 to 20% rate of missed treatment doses during the continuation phase of therapy while retaining a cost-effectiveness ratio comparable to that reported for 6-month, rifampin-containing regimens administered daily. Although 4 patients from a highly noncompliant population of 165 persons relapsed during a follow-up period of 2.5 to 12 yr, after treatment, 3 of these failures were the result of the system's inability to administer the drugs adequately. These regimens are confirmed as effective treatment alternatives that may be used in the treatment of tuberculosis in potentially unreliable patients when rifampin is contraindicated.
间歇性不含利福平方案治疗结核病的长期有效性得到了证实。在较长时间段（18至20个月）内直接给药170至190剂，在治疗的延续阶段允许有10%至20%的漏服治疗剂量率，同时保持与每日服用含利福平的6个月方案所报告的成本效益比相当。尽管在165名依从性极差的人群中有4名患者在2.5至12年的随访期内复发，但治疗后，这些治疗失败病例中有3例是由于系统无法充分给药所致。这些方案被确认为有效的治疗替代方案，当利福平禁忌时，可用于治疗潜在不可靠患者的结核病。
