Slutkin G
Public Health Rep. 1986 Sep-Oct;101(5):481-5.
Tuberculosis patients who are homeless, indigent, and alcoholic infrequently complete a course of chemotherapy, risking treatment failure, recurrence, and continued spread of infection in the community. Obstacles to successful treatment include an erratic schedule, mistrust of authority, and uncooperative or aggressive behavior. Successful management of this problem requires the use of proven case holding techniques, a correct choice of drug regimen, and a prompt and appropriate response to the patient who is lost or refuses treatment. Nine- and six-month drug regimens with proven success are now available; however, the direct observation of medication-taking should be maximized. Patient default may be further minimized by encouraging prompt notification of the health department. Occasionally, the threat or use of existing public health laws on confinement for purposes of treatment are required for noncompliant patients.
无家可归、贫困且酗酒的肺结核患者很少能完成化疗疗程,这会导致治疗失败、疾病复发,并使感染在社区中持续传播。成功治疗的障碍包括治疗计划不规律、对权威缺乏信任以及不合作或具有攻击性的行为。要成功解决这个问题,需要运用经过验证的病例管理技巧、正确选择药物治疗方案,并对失访或拒绝治疗的患者迅速做出恰当反应。目前已有经证实有效的9个月和6个月药物治疗方案;然而,应尽量加强对服药情况的直接监督。通过鼓励患者及时通知卫生部门,可进一步减少患者不按时治疗的情况。偶尔,对于不依从的患者,需要借助现行公共卫生法律中有关为治疗目的进行隔离的规定来加以威胁或实施隔离。