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头孢曲松-哌拉西林与头孢曲松-奈替米星的比较协同活性

Comparative synergistic activity of ceftriaxone-piperacillin versus ceftriaxone-netilmicin.

作者信息

Machka K, Dietz R

出版信息

Eur J Clin Microbiol. 1983 Oct;2(5):496-500. doi: 10.1007/BF02013915.

DOI:10.1007/BF02013915
PMID:6315425
Abstract

The effect of combination of ceftriaxone with piperacillin or netilmicin was studied in a total of 119 clinical isolates using the checkerboard titration technique. The isolates included Pseudomonas aeruginosa, Staphylococcus aureus, enterococci and various Enterobacteriaceae. Synergy was observed in all Streptococcus faecalis strains with both combinations. Whereas the ceftriaxone/netilmicin combination showed a higher rate of synergy against Pseudomonas aeruginosa, the rate of synergy against Enterobacteriaceae was the same for the two combinations. In no instance was antagonism encountered.

摘要

采用棋盘滴定技术，对119株临床分离菌研究了头孢曲松与哌拉西林或奈替米星联合使用的效果。这些分离菌包括铜绿假单胞菌、金黄色葡萄球菌、肠球菌和各种肠杆菌科细菌。在所有粪肠球菌菌株中，两种联合用药均观察到协同作用。头孢曲松/奈替米星联合用药对铜绿假单胞菌显示出更高的协同率，而两种联合用药对肠杆菌科细菌的协同率相同。未发现拮抗作用的情况。

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Comparative synergistic activity of ceftriaxone-piperacillin versus ceftriaxone-netilmicin.头孢曲松-哌拉西林与头孢曲松-奈替米星的比较协同活性
Eur J Clin Microbiol. 1983 Oct;2(5):496-500. doi: 10.1007/BF02013915.
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引用本文的文献

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Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use.头孢曲松。对其抗菌活性、药理特性及治疗用途的综述。
Drugs. 1984 Jun;27(6):469-527. doi: 10.2165/00003495-198427060-00001.
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Eur J Clin Microbiol. 1983 Oct;2(5):485-8. doi: 10.1007/BF02013913.
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本文引用的文献

1
Ro 13-9904: A cephalosporin with a high degree of activity and broad antibacterial activity: an invitro comparative study.Ro 13-9904：一种具有高度活性和广泛抗菌活性的头孢菌素：一项体外比较研究。
J Antimicrob Chemother. 1980 Sep;6(5):595-600. doi: 10.1093/jac/6.5.595.
2
Antimicrobial activity of netilmicin in comparison with gentamicin, sisomicin, tobramycin, and amikacin and their resistance patterns.奈替米星与庆大霉素、西索米星、妥布霉素和阿米卡星相比的抗菌活性及其耐药模式。
Arzneimittelforschung. 1980;30(3):491-5.
3
Pharmacokinetics of Rocephin, a highly active new cephalosporin with an exceptionally long biological half-life.
4
Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration.头孢曲松。对其抗菌活性和药代动力学特性的重新评估，以及关于其治疗用途的最新情况，特别提及每日一次给药。
Drugs. 1988 Jun;35(6):604-45. doi: 10.2165/00003495-198835060-00002.
头孢曲松（Rocephin）的药代动力学，一种具有超长生物半衰期的高活性新型头孢菌素。
Chemotherapy. 1981;27 Suppl 1:42-6. doi: 10.1159/000238028.
4
Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin.头孢曲松（Ro 13 - 9904）的抗菌活性，一种对β-内酰胺酶稳定的头孢菌素。
Antimicrob Agents Chemother. 1981 Mar;19(3):414-23. doi: 10.1128/AAC.19.3.414.
5
Ro 13-9904, a long-acting broad-spectrum cephalosporin: in vitro and in vivo studies.Ro 13-9904，一种长效广谱头孢菌素：体外和体内研究
Antimicrob Agents Chemother. 1980 Dec;18(6):913-21. doi: 10.1128/AAC.18.6.913.
6
Comparative in vitro activities of beta-lactam-tobramycin combinations against Pseudomonas aeruginosa and multidrug-resistant gram-negative enteric bacilli.β-内酰胺类与妥布霉素联合用药对铜绿假单胞菌和多重耐药革兰氏阴性肠道杆菌的体外比较活性
Antimicrob Agents Chemother. 1982 Jun;21(6):1003-6. doi: 10.1128/AAC.21.6.1003.
7
In vitro evaluation of Ro 13-9904.Ro 13-9904的体外评估
Antimicrob Agents Chemother. 1980 Oct;18(4):574-8. doi: 10.1128/AAC.18.4.574.
8
In vitro and in vivo antibacterial effects of combinations of beta-lactam antibiotics.β-内酰胺类抗生素组合的体外和体内抗菌作用
Antimicrob Agents Chemother. 1981 Apr;19(4):634-8. doi: 10.1128/AAC.19.4.634.
9
In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa.头孢曲松单独及与庆大霉素、妥布霉素和阿米卡星联合应用对铜绿假单胞菌的体外活性。
Antimicrob Agents Chemother. 1983 Aug;24(2):305-6. doi: 10.1128/AAC.24.2.305.
10
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Eur J Clin Microbiol. 1982 Aug;1(4):238-42. doi: 10.1007/BF02019715.